RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS follo
✦ LIBER ✦
Synthesis of deuterium and tritium labelled (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)-propionic acid (ATPA), a selective kainic acid receptor agonist
✍ Scribed by Tommy N. Johansen; Calvin R. Hawes; Gareth J. Ellis; Bjarke Ebert; Tine B. Stensbøl; Dorthe da Graça Thrige; Povl Krogsgaard-Larsen
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 315 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2135
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We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com