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Synthesis of tritium labelled 3(R)-HETE and 3(R),18(R/S)-DiHETE through a common synthetic route

✍ Scribed by Natalya V. Groza; Igor V. Ivanov; Stepan G. Romanov; Valery P. Shevchenko; Nikolai F. Myasoedov; Santosh Nigam; Galina I. Myagkova

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
101 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An efficient procedure for the synthesis of 3‐hydroxyoxylipins labelled with tritium on all double bond positions is reported. The synthetic scheme involves a joint route for the formation of tetraacetylenic precursors followed by stereoselective reduction of the triple bonds either with hydrogen or tritium. The final tritiated products were obtained with specific activities ranging from 1.65 to 1.80 Ci/mmol. Copyright Β© 2003 John Wiley & Sons, Ltd.

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