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Synthesis of tritium labeled arbaprostil and related 15- methyl prostaglandins

✍ Scribed by Richard S. P. Hsi; Ernest W. Yankee; Wayne T. Stolle

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
508 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

This report describes the synth i s of arbaprostil, I cytoprotective antiulcer a ent, an a group of relate 15-methyl rostaglandins, la%eled w I tritium at the C-1 position, [om 15(R)-and 1 S(S)-15-methylprostaglandin. D2 methyl esters. Radiolytic decomposition of the labeled product and some intermediates, and purification by preparative high performance liquid chromatography, and storage of [W]arbaprostil are also discussed.

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