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Synthesis of canrenone and related steroids labelled with tritium, carbon-14, and sulfur-35

✍ Scribed by Charles S. Markos; Clifford R. Dorn; Donald J. Zitzewitz

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
546 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

The synthesis of [l-3Hlcanrenone, [l-3 H]spironolactone, [l-3 H ] 14 potassium canrenoate, [ 22-[ 22-14C]potassium canrenoate, and [ 35Slspironolactone is reported. Tritium labelled compounds were obtained by catalytic reduction of a 3-keto-1,4-diene precursor followed by exchange of enolizable label. Carbon-14 compounds were obtained by reaction of a 17-ethynyl steroid with C02. Sulfur-35 spironolactone was synthesized by the in-situ generation of [ 35S]thiolacetic acid from [ 35S]sodium sulfide.

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