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Synthesis of tritium and carbon-14 labeled timefurone

✍ Scribed by Richard S. P. Hsi; Ronald B. Gammill; Edward G. Daniels

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
976 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

Timefurone (I), a methyl thioether analogue of khel lin (2), was labeled with tritium at the C-2 position and with carbon-14 at the C-5 position for conducting in uivo biotransformation studies with I . Tritium labeled I was prepared by lithiating and tritiating a silyllated derivative of khellinone (3) at C-2, followed by converting the labeled khellinone into I . Carbon-14 labeled I was obtained by first dismantling the pyrone ring of khellin, followed by reconstruction of the ring with incorporation of carbon-14 into the carbonyl position.

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