## Abstract Clinical findings using [^11^C]methyl 1‐[(1__R__)‐1‐phenylethyl]‐1__H__‐imidazole‐5‐carboxylate ([^11^C]MTO, 1) show high uptake in lesions of adrenocortical origin, including adenomas, but low uptake in lesions of non‐adrenocortical origin. In this paper the synthesis and preclinical e
Synthesis of three 11C-labelled methionine-containing enkephal in analogues
✍ Scribed by Kjell Någren; Ulf Ragnarsson; Bengt Långström
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 419 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0022-2135
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## Abstract ^11^C‐labelling of methionine residues in a synthetic peptide via the preparation of the corresponding protected, pure homocysteine peptide has been investigated. Complete deprotection of the peptide and specific methylation of the homocysteine residue can be performed in one step in li
Starting from the corresponding N-benzyloxycarbonyl S-benzyl homocysteine peptide benzyl esters, Met-enkephalin and two metabolites, Gly-Phe-Met and Phe-Met, have been labelled with 11C for application in positron emission tomography in vivo. All labelling experiments were accomplished in high radio
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