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Synthesis of 11C-labelled metomidate analogues as adrenocortical imaging agents

✍ Scribed by Farhad Karimi; Maria Erlandsson; Örjan Lindhe; Bengt Långström

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
154 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Clinical findings using [^11^C]methyl 1‐[(1__R__)‐1‐phenylethyl]‐1__H__‐imidazole‐5‐carboxylate ([^11^C]MTO, 1) show high uptake in lesions of adrenocortical origin, including adenomas, but low uptake in lesions of non‐adrenocortical origin. In this paper the synthesis and preclinical evaluation of two new ^11^C‐labelled analogues of MTO, [^11^C]methyl 1‐[(1__R__)‐1‐(4‐chlorophenyl)ethyl]‐1__H__‐imidazole‐5‐carboxylate ([^11^C]CLM, 2) and [^11^C]methyl 1‐[(1__R__)‐1‐(4‐bromophenyl)ethyl]‐1__H__‐imidazole‐5‐carboxylate ([^11^C]BRM, 3), using frozen‐section autoradiography, organ distribution and a metabolic study are presented. Copyright © 2008 John Wiley & Sons, Ltd.

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