l C ] d i p r e n o r p h i n e ( 1 ) , and t h e mixed a g o n i s t -a n t a g o n i s t , [ l l C ] b u p r e n o r p h i n e ( 2 1 , f o r i n v e s t i g a t i o n s o f t h e o p i a t e r e c e p t o r s y s t e n i n l i v i n g m a n u s i n g p o s i t r o n e m i s s i o n tomography (PET
Preparation of some NCA [1-11C]acid chlorides as labelling agents
✍ Scribed by S.K. Luthra; V.W. Pike; F. Brady
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 654 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0883-2889
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## Abstract Three methods are described for labeling methanesulfonyl (mesyl) chloride with no‐carrier‐added (NCA) carbon‐11 (__t__~1/2~=20.4 min; β^+^=99.8%) to provide a new labeling agent of potential value in radiopharmaceutical development for positron emission tomography (PET). Each method use
## Abstract 5(S)‐Hydroxy‐6(R)‐(N‐[1‐^11^C]acetyl)cysteinyl‐7,9‐trans‐11,14‐cis‐eicosatetraenoic acid (N‐[1‐^11^C]acetyl leukotriene E~4~) was prepared by the reaction of leukotriene E~4~ and [1‐^11^C]acetyl chloride. The product was obtained with 1.3% yield, based on [1‐^11^C]acetyl chloride. The p