✦ LIBER ✦

Preparation of NCA [1-11C]acid chlorides as labelling agents for amides

✍ Scribed by S.K. Luthra; D. Le Bars; V.W. Pike; F. Brady

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 134 KB
Volume: 26
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580260128

No coin nor oath required. For personal study only.

✦ Synopsis

l C ] d i p r e n o r p h i n e ( 1 ) , and t h e mixed a g o n i s t -a n t a g o n i s t , [ l l C ] b u p r e n o r p h i n e ( 2 1 , f o r i n v e s t i g a t i o n s o f t h e o p i a t e r e c e p t o r s y s t e n i n l i v i n g m a n u s i n g p o s i t r o n e m i s s i o n tomography (PET) ( 3 , 4 ) . Both o f t h e s e l i g a n d s were l a b e l l e d w i t h carbon-11 u s i n g t h e l a b e l l i n g a g e n t , NCA E1-l l C ] c y c l o p r o p a n e c a r b o n y l c h l o r i d e . c h l o r i d e h a s been d e v e l o p e d t o l a b e l t h e d , -a d r e n o r e c e p t o r a n t a g o n i s t , p r a z o s i n ( 5 ) . A s a n e x t e n s i o n o f t h i s work we now r e p o r t on t h e p r e p a r a t i o n of o t h e r NCA [ l -l 1 C I a c i d c h l o r i d e s (R1lCOC1; R = Me, E t , P r and cyclo-Bu) as u s e f u l a g e n t s f o r l a b e l l i n g amides.

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