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The synthesis of the neuropeptide Met-enkephalin and two metabolic fragments labelled with 11C in the methionine methyl group

✍ Scribed by Kjell Någren; Ulf Ragnarsson; Bengt Långström

Publisher
Elsevier Science
Year
1986
Weight
247 KB
Volume
37
Category
Article
ISSN
0883-2889

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✦ Synopsis

Starting from the corresponding N-benzyloxycarbonyl S-benzyl homocysteine peptide benzyl esters, Met-enkephalin and two metabolites, Gly-Phe-Met and Phe-Met, have been labelled with 11C for application in positron emission tomography in vivo. All labelling experiments were accomplished in high radiochemical yields within 30-40 min from start of the [11C]methyl iodide synthesis. Alkylations with this reagent were performed in liquid ammonia, using sodium to generate the free peptides with their reactive sulphide anions, essentially as previously described for [methyl-11C]methionine. The products were purified by liquid chromatography (LC) to a radiochemical purity of 98% or better.

📜 SIMILAR VOLUMES

The synthesis of aliphatic and aromatic
The synthesis of aliphatic and aromatic hydrocarbons containing methyl groups labelled with 11C
✍ B. Långstro̊m; S. Sjöberg 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 391 KB

## Abstract The synthesis of [1‐^11^C]pentane, [1‐^11^C]nonane, [1‐^11^C]‐ undecane, 2‐[^11^ C]methyl‐naphthalene and [^11^C]methyl‐benzene (toluene) are reported. The hydrocarbons were prepared by the coupling reaction between [^11^C]methyl iodide and the appropriate lithium organocuprate. Toluene