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Synthesis of substituted pyridines and pyridazines via ring closing metathesis

✍ Scribed by Donohoe, Timothy J.; Fishlock, Lisa P.; Basutto, José A.; Bower, John F.; Procopiou, Panayiotis A.; Thompson, Amber L.


Book ID
111980243
Publisher
Royal Society of Chemistry
Year
2009
Tongue
English
Weight
677 KB
Volume
21
Category
Article
ISSN
1359-7345

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The 1-benzazepin-2-one ring system is an important structural feature of marketed drugs, clinical candidates, and other bioactive molecules. We have developed a new benzazepinone synthesis that employs ring-closing olefin metathesis as a key step. This route provides efficient access to substituted