Synthesis of substituted 1-benzazepin-2-ones via ring-closing olefin metathesis

✍ Scribed by Scott B. Hoyt; Clare London; Min Park

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 318 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.02.022

✦ Synopsis

The 1-benzazepin-2-one ring system is an important structural feature of marketed drugs, clinical candidates, and other bioactive molecules. We have developed a new benzazepinone synthesis that employs ring-closing olefin metathesis as a key step. This route provides efficient access to substituted benzazepinones that are difficult to synthesize via existing procedures.