✦ LIBER ✦

Synthesis of structure analogues of thromboxane A2

✍ Scribed by M.F. Ansell; M.P.L. Caton; M.N. Palfreyman; K.A.J. Stuttle

Publisher: Elsevier Science
Year: 1979
Tongue: French
Weight: 117 KB
Volume: 20
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)86630-2

No coin nor oath required. For personal study only.

✦ Synopsis

AnaloguesI of thromboxane A2 (TXA2) in which the ether linkages are replaced by carbon groupings have been synthesised by elaboration of a connnercially available pinene derivative IIb.

📜 SIMILAR VOLUMES

Oxyallyls in synthesis: Preparation of t

Oxyallyls in synthesis: Preparation of tricyclic thromboxane A2 analogues

✍ Kevin G. Bowers; John Mann 📂 Article 📅 1985 🏛 Elsevier Science 🌐 French ⚖ 126 KB

On the structure of thromboxane A2

✍ Josef Fried; Ziqing Zhou; Chen Chien-Kuang 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 131 KB

The reactions of the Z-alkoxyoxetane 5 with sodium azide and methanol yield the a-azidoether 7 and the dimethyl acetal S, respectively, paralleling reactions reported for TXA2. The hydrolysis of 5 reported by Bruice to involve general acid catalysis proceeds at a rate similar to that reported for T

Synthesis of a dioxabicyclooctane analog

Synthesis of a dioxabicyclooctane analogue of thromboxane A2.

✍ M.F. Ansell; M.P.L. Caton; C.O. Ugwuegbulam 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 82 KB

Synthesis of thromboxane A2 analog, dl-(

Synthesis of thromboxane A2 analog, dl-(9,11)-methano-(11,12)-amino thromboxane A2

✍ Shunji Kosuge; Masaki Hayashi; Nobuyuki Hamanaka 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 220 KB

A synthesis of nitrogen containing thromboxane A2 analog, c-(9,11)methano-(11,12)-amino thromboxane A2 (a is described. Thromboxane A2 (TXA~) 1s an extremely unstable substance possessing very important biological actlvltles (platelet aggregation and vasoconstrlctlon).

A simple synthesis of a stable thromboxa

A simple synthesis of a stable thromboxane A2 analogue

✍ Paul Barraclough 📂 Article 📅 1980 🏛 Elsevier Science 🌐 French ⚖ 202 KB

A simple synthetic route, which appears to have some general utility, has been used to obtain a Bicyclo[2.2.l]heptane analogue of Thromboxane A2. Thromboxane A2 (TXA2), an unstable metabolite of arachidonic acid in platelets,

Synthesis of thromboxane A2 analog dl-(9

Synthesis of thromboxane A2 analog dl-(9,11),(11,12)-dideoxa-(9,11),(11,12)-dimethylene thromboxane A2

✍ Shuichi Ohuchida; Nobuyuki Hamanaka; Masaki Hayashi 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 215 KB

The thromboxane A2 analog, dl-(9,11),( 11,12)-dideoxa-(9,11),(11,12)dimethylene thromboxane A2 (TX A2) has been synthesized; the compound showed high agonist activities on platelet aggregation and the aorta contracting activities. In 1975, Samuelsson et al. discovered a new family of arachidonic aci