AnaloguesI of thromboxane A2 (TXA2) in which the ether linkages are replaced by carbon groupings have been synthesised by elaboration of a connnercially available pinene derivative IIb.
Oxyallyls in synthesis: Preparation of tricyclic thromboxane A2 analogues
β Scribed by Kevin G. Bowers; John Mann
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 126 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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A simple synthetic route, which appears to have some general utility, has been used to obtain a Bicyclo[2.2.l]heptane analogue of Thromboxane A2. Thromboxane A2 (TXA2), an unstable metabolite of arachidonic acid in platelets,
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This study was designed to determine the effects of thromboxane A2 (TxA2) on the distribution of vascular resistance, lung weight, and microvascular permeability in isolated dog lungs perfused at a constant pressure with autologous blood. The stable TxA z analogue (STA2; 30 I~g, n = 5) caused an inc