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Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a nevirapine analogue

✍ Scribed by J. M. Bakke; J. Riha

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
62 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A new method for preparing 3‐amino‐2‐chloropyridines with a substituent (methyl, phenyl, carbox‐amide, methoxycarbonyl, acetyl, benzoyl and cyano) at the 4‐position has been developed. An isoquinoline analogue of the reverse transcriptase inhibitor Nevirapine has been synthesized from the 4‐amino‐3‐chloroisoquinoline.

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## Abstract 4‐Nitro‐pyridine‐__N__‐oxides are reacted with ethylchloroformate and trimethylsilyl cyanide to give 4‐chloro‐2‐cyanopyridine. J. Heterocyclic Chem., (2011).