𝔖 Bobbio Scriptorium
✦   LIBER   ✦

On the structure of thromboxane A2

✍ Scribed by Josef Fried; Ziqing Zhou; Chen Chien-Kuang

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
131 KB
Volume
25
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The reactions of the Z-alkoxyoxetane 5 with sodium azide and methanol yield the a-azidoether 7 and the dimethyl acetal S, respectively, paralleling reactions reported for TXA2.

The hydrolysis of 5 reported by Bruice to involve general acid catalysis proceeds at a rate similar to that reported for TXA2.

All these cleavage reactions are most likely to proceed by the same mechanism.

These findings support structure 1 for TXA2.

πŸ“œ SIMILAR VOLUMES

Synthesis of structure analogues of thro
Synthesis of structure analogues of thromboxane A2
✍ M.F. Ansell; M.P.L. Caton; M.N. Palfreyman; K.A.J. Stuttle πŸ“‚ Article πŸ“… 1979 πŸ› Elsevier Science 🌐 French βš– 117 KB

AnaloguesI of thromboxane A2 (TXA2) in which the ether linkages are replaced by carbon groupings have been synthesised by elaboration of a connnercially available pinene derivative IIb.

Synthesis of thromboxane A2 analog, dl-(
Synthesis of thromboxane A2 analog, dl-(9,11)-methano-(11,12)-amino thromboxane A2
✍ Shunji Kosuge; Masaki Hayashi; Nobuyuki Hamanaka πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 220 KB

A synthesis of nitrogen containing thromboxane A2 analog, c-(9,11)methano-(11,12)-amino thromboxane A2 (a is described. Thromboxane A2 (TXA~) 1s an extremely unstable substance possessing very important biological actlvltles (platelet aggregation and vasoconstrlctlon).

Synthesis of thromboxane A2 analog dl-(9
Synthesis of thromboxane A2 analog dl-(9,11),(11,12)-dideoxa-(9,11),(11,12)-dimethylene thromboxane A2
✍ Shuichi Ohuchida; Nobuyuki Hamanaka; Masaki Hayashi πŸ“‚ Article πŸ“… 1979 πŸ› Elsevier Science 🌐 French βš– 215 KB

The thromboxane A2 analog, dl-(9,11),( 11,12)-dideoxa-(9,11),(11,12)dimethylene thromboxane A2 (TX A2) has been synthesized; the compound showed high agonist activities on platelet aggregation and the aorta contracting activities. In 1975, Samuelsson et al. discovered a new family of arachidonic aci