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Synthesis of thromboxane A2 analog DL-(9,11), (11,12)-dideoxa-(9,11)-epithio-(11,12)-methylene-thromboxane A2

โœ Scribed by Shuichi Ohuchida; Nobuyuki Hamanaka; Masaki Hayashi

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
263 KB
Volume
22
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A synthesis of the thromboxane A2 analog,&-(9,11),(11,12)-dideoxa-(9,11)-epithio-(11,12)-methylene-thromboxane A2 is described.

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The thromboxane A2 analog, dl-(9,11),( 11,12)-dideoxa-(9,11),(11,12)dimethylene thromboxane A2 (TX A2) has been synthesized; the compound showed high agonist activities on platelet aggregation and the aorta contracting activities. In 1975, Samuelsson et al. discovered a new family of arachidonic aci

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A synthesis of nitrogen containing thromboxane A2 analog, c-(9,11)methano-(11,12)-amino thromboxane A2 (a is described. Thromboxane A2 (TXA~) 1s an extremely unstable substance possessing very important biological actlvltles (platelet aggregation and vasoconstrlctlon).