𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of a stable analogue of thromboxane A1 (±)-9a-homo-(11,12)-deoxa-(11,12)-methylene thromboxane A1

✍ Scribed by M.F. Ansell; M.P.L. Caton; J.S. Mason

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
115 KB
Volume
22
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The thromboxane A1 (TXAI) analogue (1) has been synthesised from the ketone (2).

Thromboxane AZ (TXAZ), an unstable (t% 32sec. at 37O) metabolite of the prostaglandin endo-

📜 SIMILAR VOLUMES

Synthesis of thromboxane A2 analog dl-(9
Synthesis of thromboxane A2 analog dl-(9,11),(11,12)-dideoxa-(9,11),(11,12)-dimethylene thromboxane A2
✍ Shuichi Ohuchida; Nobuyuki Hamanaka; Masaki Hayashi 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 215 KB

The thromboxane A2 analog, dl-(9,11),( 11,12)-dideoxa-(9,11),(11,12)dimethylene thromboxane A2 (TX A2) has been synthesized; the compound showed high agonist activities on platelet aggregation and the aorta contracting activities. In 1975, Samuelsson et al. discovered a new family of arachidonic aci

Synthesis of thromboxane A2 analog, dl-(
Synthesis of thromboxane A2 analog, dl-(9,11)-methano-(11,12)-amino thromboxane A2
✍ Shunji Kosuge; Masaki Hayashi; Nobuyuki Hamanaka 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 220 KB

A synthesis of nitrogen containing thromboxane A2 analog, c-(9,11)methano-(11,12)-amino thromboxane A2 (a is described. Thromboxane A2 (TXA~) 1s an extremely unstable substance possessing very important biological actlvltles (platelet aggregation and vasoconstrlctlon).

Assignment of the 1H and 13C NMR spectra
Assignment of the 1H and 13C NMR spectra of 9-deoxo-9a-aza-9a-homoerythromycin A, 9-deoxo-9a-aza-9a-homoerythromycin A 11,12-hydrogenborate and azithromycin 11,12-hydrogenborate
✍ Miguel Bayod-Jasanada; Rodrigo J. Carbajo; Fernando López-Ortiz 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 276 KB 👁 1 views

The 1H and 13C NMR spectra of 9-deoxo-9a-aza-9a-homoerythromycin A, its 11,12-hydrogenborate derivative and azithromycin 11,12-hydrogenborate were unambiguously assigned using a combination of 1D and 2D HÈC correlation spectra.