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Synthesis of thromboxane A2 analog DL-(9,11), (11,12)-dideoxa-(9,11)-methylene-(11,12)-epithio-thromboxane A2 methyl ester

โœ Scribed by Shunji Kosuge; Nobuyuki Hamanaka; Masaki Hayashi

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
196 KB
Volume
22
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A synthesis of the thromboxane A2 analog, a-(9,11), (11,12)-dideoxa-(9,11)-methylene-(11,12)-epithio-thromboxane A2 methyl ester 2, is described.

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The thromboxane A2 analog, dl-(9,11),( 11,12)-dideoxa-(9,11),(11,12)dimethylene thromboxane A2 (TX A2) has been synthesized; the compound showed high agonist activities on platelet aggregation and the aorta contracting activities. In 1975, Samuelsson et al. discovered a new family of arachidonic aci

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