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Synthesis of statine and its analogues by homogeneous asymmetric hydrogenation

โœ Scribed by T. Nishi; M. Kitamura; T. Ohkuma; R. Noyori

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
280 KB
Volume
29
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Diastereoselective hydrogenation of N-protected y-amino fi-keto esters catalyzed by BINAP-Ru(II)

complexes provides an efficient entry to the statine series with high enantiomeric purities.

๐Ÿ“œ SIMILAR VOLUMES

A novel short and efficient asymmetric s
A novel short and efficient asymmetric synthesis of statine analogues
โœ Ralf M. Devant; Hans-E. Radunz ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 220 KB

The statine analogues la\_c have been obtained in high optical purity via addition of the chit-al acetate enolate 4 to the a-aminoaldehydes 5a\_c, followed by transesterification.

Asymmetric Synthesis of the Roche Ester
Asymmetric Synthesis of the Roche Ester and its Derivatives by Rhodium-INDOLPHOS-Catalyzed Hydrogenation
โœ Jeroen Wassenaar; Mark Kuil; Joost N.โ€…H. Reek ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 178 KB ๐Ÿ‘ 2 views

## Abstract (__S__)โ€3โ€Hydroxyโ€2โ€methylpropionate, known as the Roche ester, and several of its derivatives were successfully synthesized through asymmetric rhodiumโ€catalyzed hydrogenation, using INDOLPHOS (diisopropyl{1โ€[(__S__)โ€3,5โ€dioxaโ€4โ€phosphacyclohepta[2,1โ€__a__;3,4โ€__aโ€ฒ__]dinaphthalenโ€4โ€yl]โ€