## Abstract (__S__)‐3‐Hydroxy‐2‐methylpropionate, known as the Roche ester, and several of its derivatives were successfully synthesized through asymmetric rhodium‐catalyzed hydrogenation, using INDOLPHOS (diisopropyl{1‐[(__S__)‐3,5‐dioxa‐4‐phosphacyclohepta[2,1‐__a__;3,4‐__a′__]dinaphthalen‐4‐yl]‐
✦ LIBER ✦
ChemInform Abstract: Asymmetric Synthesis of the Roche Ester and Its Derivatives by Rhodium-INDOLPHOS-Catalyzed Hydrogenation.
✍ Scribed by Jeroen Wassenaar; Mark Kuil; Joost N. H. Reek
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 41 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The reaction applies a HCOOH/NEt~3~ mixture as a hydrogen source and a chiral Rh‐complex as a catalyst.