𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Asymmetric Synthesis of the Roche Ester and its Derivatives by Rhodium-INDOLPHOS-Catalyzed Hydrogenation

✍ Scribed by Jeroen Wassenaar; Mark Kuil; Joost N. H. Reek

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
178 KB
Volume
350
Category
Article
ISSN
1615-4150

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

(S)‐3‐Hydroxy‐2‐methylpropionate, known as the Roche ester, and several of its derivatives were successfully synthesized through asymmetric rhodium‐catalyzed hydrogenation, using INDOLPHOS (diisopropyl{1‐[(S)‐3,5‐dioxa‐4‐phosphacyclohepta[2,1‐a;3,4‐a′]dinaphthalen‐4‐yl]‐3‐methyl‐2‐indolyl}phosphine) as the chiral ligand, in excellent yield and the highest ee reported up to now (TOF over 5500 h^−1^ at 25 °C; up to 98% ee at −40 °C).

📜 SIMILAR VOLUMES

ChemInform Abstract: Convenient General
ChemInform Abstract: Convenient General Asymmetric Synthesis of Roche Ester Derivatives Through Catalytic Asymmetric Hydrogenation: Steric and Electronic Effects of Ligands.
✍ Cyrielle Pautigny; Severine Jeulin; Tahar Ayad; Zhaoguo Zhang; Jean-Pierre Genet 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v