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Synthesis of some 5-halogenovinyl derivatives of uracil and their conversion into 2?-deoxyribonucleosides

✍ Scribed by Barr, Philip J.; Jones, A. Stanley; Verhelst, Gabriel; Walker, Richard T.


Book ID
118126355
Publisher
Royal Society of Chemistry
Year
1981
Weight
848 KB
Volume
0
Category
Article
ISSN
1472-7781

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πŸ“œ SIMILAR VOLUMES


Incorporation of 5-substituted uracil de
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5-(1-Hydroxyethyl)uracil, prepared by the reduction of 5-acetyluracil with sodium borohydride, has been dehydrated with formic acid to give 5-vinyluracil and a dimer of 5-vinyluracil, trans 1,3-bis (uracil-5-yl)but-l-ene. These compounds have also been prepared with a tritium label in an identified

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## Abstract The synthesis of 5‐[^3^H‐ethynyl]uracil and 5‐acetyl[6‐^3^H]uracil in good yield and of a medium specific activity ( > 40 mCi/mmol) is described. The compounds are necessary for following the incorporation of these and other derived 5‐substituted uracils into DNA and also for studying t