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Synthesis and Incorporation of C(5′)-Ethynylated Uracil-Derived Phosphoramidites into RNA.

✍ Scribed by Simon Eppacher; Markus Christen; Andrea Vasella


Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis of 5′-C-H
✍ G. WANG; P. J. MIDDLETON; Y.-Z. AN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Synthesis of 5'-C-Hydroxyalkylthymidines and Their Incorporation into Oligodeoxynucleotides. -Starting from known thymidine derivatives, title compounds (VII), (IX), and (XI) are prepared. Incorporation may be achieved by conversion to side-chain acetylated phosphoramidites. -(WANG,