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Incorporation of 5-substituted uracil derivatives into nucleic acids—I: Synthesis of some 5-substituted uracils

✍ Scribed by C.H. Evans; A.S. Jones; R.T. Walker

Publisher
Elsevier Science
Year
1973
Tongue
French
Weight
293 KB
Volume
29
Category
Article
ISSN
0040-4020

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✦ Synopsis

5-(1-Hydroxyethyl)uracil, prepared by the reduction of 5-acetyluracil with sodium borohydride, has been dehydrated with formic acid to give 5-vinyluracil and a dimer of 5-vinyluracil, trans 1,3-bis (uracil-5-yl)but-l-ene. These compounds have also been prepared with a tritium label in an identified position and with a high specific activity such that their incorporation into nucleic acids can be monitored.

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