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The synthesis of some tritiated 5-substituted uracil derivatives

✍ Scribed by P. J. Barr; A. S. Jones; R. T. Walker; L. Bohá

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
273 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of 5‐[^3^H‐ethynyl]uracil and 5‐acetyl[6‐^3^H]uracil in good yield and of a medium specific activity ( > 40 mCi/mmol) is described. The compounds are necessary for following the incorporation of these and other derived 5‐substituted uracils into DNA and also for studying the metabolism and mode of action of their deoxynucleosides, some of which possess antiviral properties.

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