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Synthesis, characterization, and biological activity of some aza-uracil derivatives

✍ Scribed by Ahmed Ahmed El-Barbary; Yehia Ahmed Hafiz; Mohamed Shaker Abdel-Wahed

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
169 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Thiation of 1 by LR gave the corresponding 3,5‐dithioxo derivative 2 and the trimer 3. Methylation of 1 afforded the S‐methyl derivative 4. Compound 1 was fused with 6‐bromo‐2‐phenyl‐benzo[1,3‐d]oxazin‐4‐one (5) and gave 6. Condensation of 1 with some acid derivatives 7a, 7b, 7c, 7d and/or 8a, 8b, 8c yielded thiadiazolo‐triazine derivatives 9a, 9b, 9c, 9d and 10a, 10b, 10c. Compounds 9a,9c and 10c were hydrolyzed to furnish 11a, 11b, 11c Acetylation of 14 afforded mono‐ and diacetyl‐derivatives 15 and 16. Benzoylation of 14 afforded mono‐ and dibezoyl‐derivatives 17 and 18. 14 with some aromatic aldehydes yielded 9a, 9b, 9c. Reacting 14 with phenyl (iso‐ and/or isothio‐) cyanate gave the urea derivatives 20a,20b. Thiation of 14 with P~4~S~10~ furnished 21. The newly synthesized compounds were tested as antimicrobial agents. J. Heterocyclic Chem., (2011)

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