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Synthesis of 1-(dihydroxypropyl)-5-substituted uracils

โœ Scribed by Andrzej Gondela; Krzysztof Walczak

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
108 KB
Volume
44
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Novel 1-(dihydroxypropyl)-5-substituted uracils were synthesized in the reaction of 1-(4-nitrophenyl)-5-substituted uracil derivatives with appropriate aminopropanediols under mild conditions. In the case of 3-amino-1,2-propanediol both racemic and enantiomerically enriched products were obtained. These compounds may be considered as new building blocks for oligonucleotide synthesis.

๐Ÿ“œ SIMILAR VOLUMES

Incorporation of 5-substituted uracil de
Incorporation of 5-substituted uracil derivatives into nucleic acidsโ€”I: Synthesis of some 5-substituted uracils
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5-(1-Hydroxyethyl)uracil, prepared by the reduction of 5-acetyluracil with sodium borohydride, has been dehydrated with formic acid to give 5-vinyluracil and a dimer of 5-vinyluracil, trans 1,3-bis (uracil-5-yl)but-l-ene. These compounds have also been prepared with a tritium label in an identified

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