A convenient synthesis of 1-ethoxymethyl-5-nitro-6-substituted uracils
โ Scribed by Rachid Benhida; Anne-Marie Aubertin; David S Grierson; Claude Monneret
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 204 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Novel 1-(dihydroxypropyl)-5-substituted uracils were synthesized in the reaction of 1-(4-nitrophenyl)-5-substituted uracil derivatives with appropriate aminopropanediols under mild conditions. In the case of 3-amino-1,2-propanediol both racemic and enantiomerically enriched products were obtained. T
Direct and indirect electrochemical reduction of aryl halides in the presence of the uracil anion in dimethylsulfoxide yields the corrsponding S-aryl uracils by an SRNI mechanism. Nucleophilic aromatic substitution catalyzed by electron injection (electrochemical, photochemical, solvated electrons,
## Abstract The reaction of silylated 6โsubstituted uracils 5 with methyl 2,3,5โtriโ__O__โbenzoylโฮฑโDโarabinofuranoside (3) in the presence of trimethylsilyl trifluoromethanesulfonate (TMS triflate) afforded a mixture of the corresponding protected __N__^1^,__N__^3^โbis(arabinofuranosyl)uracils 6 a
Sumnary: A highly efficient and general method for the synthesis of 5-(2-acylethynyl)-2,4dimethoxypyrimidines starting from 2,4-dimethoxy-5-/?r(brimethylsilyl)ethynyl~pyrimidine is described. The 5-(2-acylethynyl)-2,4-dimethoxypyrimidines have b?en converted to 5-(2-acyl-l-iodovinyl) uracils and 5-(