Formal synthesis of (β)-N-acetylneuramin
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Eric A Voight; Christian Rein; Steven D Burke
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Article
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2001
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Elsevier Science
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French
β 83 KB
A formal total synthesis of (-)-N-acetylneuraminic acid (Neu5Ac), the most naturally abundant sialic acid, has been accomplished using a rigid 6,8-dioxabicyclo[3.2.1]octane template for stereoselective introduction of all oxygen and nitrogen functionality. The template was obtained via a novel ketal