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Synthesis of the Bryostatin 1 Northern Hemisphere (C1−C16) via Desymmetrization by Ketalization/Ring-Closing Metathesis

✍ Scribed by Voight, Eric A.; Seradj, Hassan; Roethle, Paul A.; Burke, Steven D.


Book ID
126439839
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
92 KB
Volume
6
Category
Article
ISSN
1523-7060

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✍ Kai Gerlach; Monika Quitschalle; Markus Kalesse 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 211 KB

The synthesis of the strained epothilone analog containing a ten-membered ring as well as the northern hemisphere of epothilone A is described. This approach, using the ring closing metathesis reaction, is a solution to the lack of stereocontrol observed in the ring closing metathesis reaction utili