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Synthesis of the northern hemisphere of epothiline a by a ten-membered ring closing metathesis reaction

✍ Scribed by Kai Gerlach; Monika Quitschalle; Markus Kalesse

Book ID
104261334
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
211 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of the strained epothilone analog containing a ten-membered ring as well as the northern hemisphere of epothilone A is described. This approach, using the ring closing metathesis reaction, is a solution to the lack of stereocontrol observed in the ring closing metathesis reaction utilized in the synthesis of the epothilone backbone by other groups.

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