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Total Synthesis of the Terpenoid Buddledone A: 11-Membered Ring-Closing Metathesis

✍ Scribed by Cai, Zhengxin; Yongpruksa, Nattawut; Harmata, Michael


Book ID
120500453
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
252 KB
Volume
14
Category
Article
ISSN
1523-7060

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Total synthesis of octalactin A via ring
✍ Keith R Buszek; Nagaaki Sato; Youngmee Jeong πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 93 KB

A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.