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Total synthesis of (−)-nakadomarin A: alkyne ring-closing metathesis

✍ Scribed by Pavol Jakubec; Andrew F. Kyle; Jonás Calleja; Darren J. Dixon

Book ID
113929983
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
434 KB
Volume
52
Category
Article
ISSN
0040-4039

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Total synthesis of octalactin A via ring
Total synthesis of octalactin A via ring-closing metathesis reaction
✍ Keith R Buszek; Nagaaki Sato; Youngmee Jeong 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 93 KB

A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.