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Total synthesis of octalactin A via ring-closing metathesis reaction

✍ Scribed by Keith R Buszek; Nagaaki Sato; Youngmee Jeong

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 93 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)02078-0

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✦ Synopsis

A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.

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