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Total synthesis of (−)- and (±)-frontalin via ring-closing metathesis

✍ Scribed by Matthias Scholl; Robert H. Grubbs

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
215 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Racemic and enantiopure targets containing the 6,8-dioxabicycio [3.2.1]octane skeleton, can be conveniently synthesized from monocyclic diene precursors using an intramolecular ruthenium-catalyzed ring-closing metathesis reaction as the key step.

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Total synthesis of octalactin A via ring
Total synthesis of octalactin A via ring-closing metathesis reaction
✍ Keith R Buszek; Nagaaki Sato; Youngmee Jeong 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 93 KB

A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.

ChemInform Abstract: Total Synthesis of
ChemInform Abstract: Total Synthesis of Octalactin A via Ring-Closing Metathesis Reaction.
✍ Keith R. Buszek; Nagaaki Sato; Youngmee Jeong 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

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