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Cyclic sulfonamides via the ring-closing metathesis reaction

✍ Scribed by Paul R. Hanson; Donald A. Probst; Randall E. Robinson; Mei Yau

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
244 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The first examples of ring-closing metathesis (RCM) reactions on allyl-and vinylsulfonamide templates 1 and 2 catalyzed by the Grubbs ruthenium alkylidene 3 are described. The rate of cyclization of these reactions are sensitive to simple olefin substitution. These RCM reactions yield novel cyclic allyl-and vinylsultams 4 and 5 and represent our initial efforts toward the construction of novel sulfonamides.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Cyclic Sulfonamides
ChemInform Abstract: Cyclic Sulfonamides via the Ring-Closing Metathesis Reaction.
✍ Paul R. Hanson; Donald A. Probst; Randall E. Robinson; Mei Yau πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 2 views

Cyclic Sulfonamides via the Ring-Closing Metathesis Reaction. -Ring closing metathesis of various allyl-and vinylsulfonylamides in the presence of Grubb's ruthenium catalyst yields novel cyclic allyl-and vinylsultams. In the case of substrate (IX), the pyrrole (X) is formed instead of the expected

Solid-phase synthesis of cyclic sulfonam
Solid-phase synthesis of cyclic sulfonamides employing a ring-closing metathesis–cleavage strategy
✍ Richard C.D Brown; JosΓ© L Castro; Jean-Dominique Moriggi πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 188 KB

Ring-closing olefin metathesis using the Grubbs catalyst was applied to the cyclisative release of resin-bound sulfonamides. Flexible linkers apparently facilitated the cyclisation-cleavage, allowing a number of novel cyclic sulfonamides to be prepared in good yields using catalytic amounts of the G