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Synthesis of sesquiterpene antitumor lactones. 5. Total synthesis of vernolepin. 2. Stereocontrolled synthesis of (.+-.)-vernolepin

✍ Scribed by Iio, Hideo; Isobe, Minoru; Kawai, Tatsuhiko; Goto, Toshio

Book ID: 127089448
Publisher: American Chemical Society
Year: 1979
Tongue: English
Weight: 763 KB
Volume: 101
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja00514a034

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## VernolepiniI)l is a novel elemanolide dilactone tumor inhibitor which has been isolated during the course of searching for antitumor agents from plant sources. ' No substantial progress toward partial synthesis of I has been reported. Our studies, aimed at total synthesis,