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Model studies directed toward the total synthesis of vernolepin: construction of the α-methylene-δ-lactone portion of vernolepin.

✍ Scribed by Paul A. Grieco; Kunio Hiroi

Publisher
Elsevier Science
Year
1973
Tongue
French
Weight
192 KB
Volume
14
Category
Article
ISSN
0040-4039

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✦ Synopsis

VernolepiniI)l is a novel elemanolide dilactone tumor inhibitor which has been isolated

during the course of searching for antitumor agents from plant sources. ' No substantial progress toward partial synthesis of I has been reported. Our studies, aimed at total synthesis,

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