Studies directed towards the asymmetric total synthesis of antileukemic lignan lactones. Synthesis of optically pure key intermediate and its utility

Studies directed towards the asymmetric

Studies directed towards the asymmetric total synthesis of antileukemic lignan lactones —synthesis of (−)-podorhizon—

✍ Kiyoshi Tomioka; Hidemichi Mizuguchi; Kenji Koga 📂 Article 📅 1978 🏛 Elsevier Science 🌐 French ⚖ 205 KB

Some biologically potent natural lignans having bis-benzylbutyrolactone skeleton, steganacin (s', podophyllotoxin (z2, (-)-trans-2-(3,4,5\_trimethoxy benzyl)-3-(3,4-methylenedioxybenzyl)butyrolactone (3)', are known to be optically rV active. Interestingly steganacin has the absolute configuration o