Studies directed towards the asymmetric total synthesis of antileukemic lignan lactones —synthesis of (−)-podorhizon—

✍ Scribed by Kiyoshi Tomioka; Hidemichi Mizuguchi; Kenji Koga

• Publisher: Elsevier Science
• Year: 1978
• Tongue: French
• Weight: 205 KB
• Volume: 19
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)85705-1

✦ Synopsis

Some biologically potent natural lignans having bis-benzylbutyrolactone skeleton, steganacin (s', podophyllotoxin (z2, (-)-trans-2-(3,4,5_trimethoxy benzyl)-3-(3,4-methylenedioxybenzyl)butyrolactone (3)', are known to be optically rV active. Interestingly steganacin has the absolute configuration opposite to