Synthesis of sesquiterpene antitumor lactone I a new synthesis of the cis-fused δ-valerolactone AB ring model in vernolepin and vernomenin

✍ Scribed by Takeshi Wakamatsu; Hiromu Hara; Yoshio Ban

• Publisher: Elsevier Science
• Year: 1979
• Tongue: French
• Weight: 240 KB
• Volume: 20
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)86109-8

✦ Synopsis

Reactlon of (5) with chloromethyl methyl ether undergoes successively stereo and regioselectlve alkylatlon. Compound (6) was subsequently transformed to the cls-fused angular vinyl 6-valerolactone (7).

Vernolepln (1) and vernomenin (2), 1 novel elemanollde bls-a-methylenelactones, are the malor constituents of Vernonza hymenolepzs.