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Synthesis of sesquiterpene antitumor lactones. 2. A new stereocontrolled total synthesis of (.+-.)-vernolepin

โœ Scribed by Isobe, Minoru; Iio, Hideo; Kawai, Tatsuhiko; Goto, Toshio


Book ID
121341559
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
415 KB
Volume
100
Category
Article
ISSN
0002-7863

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Synthesis of sesquiterpene antitumor lac
โœ Takeshi Wakamatsu; Hiromu Hara; Yoshio Ban ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 240 KB

Reactlon of (5) with chloromethyl methyl ether undergoes successively stereo and regioselectlve alkylatlon. Compound (6) was subsequently transformed to the cls-fused angular vinyl 6-valerolactone (7). Vernolepln (1) and vernomenin (2), 1 novel elemanollde bls-a-methylenelactones, are the malor con