Synthesis of radioiodinated 2′-iodobutyrophenone derivatives
✍ Scribed by Iwao Nakatsuka; Kunio Shiba; Hideo Saji; Akira Yoshitake; Akira Yokoyama
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 550 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
To develop new radioligands labelled with radioiodine (^125^I, ^131^I and ^121^I) for in vitro and in vivo dopamine receptor studies, three iodinated butyrophenones (2′‐iodospiperone, 2′‐iodotrifluperidol and 2′‐iodohaloperidol) were designed, synthesized and labelled with ^125^I.
📜 SIMILAR VOLUMES
Rhodamine-123 (Rh123) w a s i o d i n a t e d w i t h l z 3 I i n presence of Iodogen. Y i e l d of t h e l a b e l l e d Rh123 v a r i e d g r e a t l y depending upon v a r i o u s r e a c t i o n parameters. Optimum r e a c t i o n c o n d i t i o n s w i t h r e s p e c t t o m o l a r i t y and
## Abstract Rhodamine‐123 (Rh123) was iodinated with ^123^I in presence of Iodogen. Yield of the labelled Rh123 varied greatly depending upon various reaction parameters. Optimum reaction conditions with respect to molarity and pH of the buffer, reaction time, amounts of iodogen, carrier iodide and