Electrophilic radioiodination of tyrosine derivatives
β Scribed by Farah K.; Farouk N.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- French
- Weight
- 271 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2135
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π SIMILAR VOLUMES
## Abstract To develop new radioligands labelled with radioiodine (^125^I, ^131^I and ^121^I) for in vitro and in vivo dopamine receptor studies, three iodinated butyrophenones (2β²βiodospiperone, 2β²βiodotrifluperidol and 2β²βiodohaloperidol) were designed, synthesized and labelled with ^125^I.
A procedure for the preparation of a radioiodinated derivative of ganglioside GMl has been devised. Carbon 6 of the terminal galactosyl residue of GMI was converted to an aldehyde by galactose oxidase. The adduct formed by this oxidation product of GMI with tyramine was reduced with sodium cyanoboro