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A procedure for the radioiodination of a ganglioside derivative

✍ Scribed by Nancy Klemm; Song-Nan Su; Barbara Harnacker; Ingming Jeng

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
291 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

A procedure for the preparation of a radioiodinated derivative of ganglioside GMl has been devised. Carbon 6 of the terminal galactosyl residue of GMI was converted to an aldehyde by galactose oxidase. The adduct formed by this oxidation product of GMI with tyramine was reduced with sodium cyanoborohydride. The tyramine moiety covalently attached to GMl was then labelled by the conventional iodine chloride procedure. The technique described herein is simple and economical for the preparation of a highly radioactive G M l derivative.

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