𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and structural characterization of the dilactone derivative of GD1a ganglioside

✍ Scribed by Giovanni Fronza; Günther Kirschner; Domenico Acquotti; Rosaria Bassi; Luigina Tagliavacca; Sandro Sonnino

Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
562 KB
Volume
182
Category
Article
ISSN
0008-6215

No coin nor oath required. For personal study only.

✦ Synopsis

Treatment of GD1a [alpha-Neu5Ac-(2----3)-beta-GalNAc-(1----4)-[alpha- Neu5Ac-(2----3)]-beta-Gal-(1----4)-beta-Glc-(1----1)-Cer] with dicyclohexylcarbodi-imide in anhydrous methyl sulfoxide affords 94-98% of GD1a-dilactone. The involvement of the carboxyl groups of the two sialic acid residues in the lactone rings was proved by ammoniolysis and reduction experiments, which gave ganglioside derivatives containing the amide of sialic acid and N-acetylneuraminulose, respectively. 1H-N.m.r. spectroscopy showed that the lactone rings involved position 2 of each galactose residue in the ester linkages.

📜 SIMILAR VOLUMES

Synthesis, structure, and conformation o
Synthesis, structure, and conformation of the dilactone derivative of Gd1b ganglioside
✍ Giovanni Fronza; Gunther Kirschner; Domenico Acquotti; Sandro Sonnino 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 575 KB

Treatment of DG1b, beta-Gal-(1----3)-beta-GalNAc-(1---- 4)-[alpha-Neu5Ac-(2----8)-alpha-Neu5Ac-(2---- 3)]-beta-Gal-(1----4)-beta-Glc-(1----1)-Cer, with dicyclohexylcarbodi-imide in anhydrous methyl sulfoxide affords 95-98% of GD1b-dilactone. The carboxyl groups of the two sialic acid units are invol

A facile, systematic synthesis of gangli
A facile, systematic synthesis of ganglio-series gangliosides: Total synthesis of gangliosides GM1 and GD1a
✍ Akira Hasegawa; Takao Nagahama; Makoto Kiso 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 337 KB

Mammals, birds, amphibians, and teleost fish all have similar brain gangliosides. These gangliosides are of the ganglio-series with predominantly, gangliotetraose, P-o-Gal-(1 + 3)-fl-D-GalNAc-(1 + +&o-Gal-( 1+ 4)-~-Gk, as the neutral oligosaccharide, though with a varying degree of sialylation. Sinc

Synthesis and Structural Characterizatio
Synthesis and Structural Characterization of Azatitanacyclobutane Derivatives
✍ Rüdiger Beckhaus; Martin Wagner; Ruimin Wang 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 475 KB 👁 2 views

The titanocene vinylidene intermediate [Cp\* 2 Ti=C=CH 2 ] (9) The azatitanacyclobutane [Cp\* 2 Ti{ϪNPhϪC(Ph)(H)Ϫ(C= CH 2 )Ϫ}] (22) was formed from the reaction between 9 and reacted with the carbodiimides RϪN=C=NϪR [R = p-CH 3 C 6 H 4 (19a), C 6 H 11 (19b)] to give the N=C-cycloaddition benzylidene

Synthesis and structural characterizatio
Synthesis and structural characterization of isomeric coumarino-1,2-oxaphosphole derivatives
✍ Petar J. Petrov; Alexi A. Alexiev; Galin Petrov; Gianluca Giorgi 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 105 KB

The coumarino-[3,4-c]-3H-10-methyl-2-oxo-2-phenyl-1,2-oxaphosphole was prepared by the addition of PhPCl 2 to 3-acetylcoumarin in the presence of acetic anhydride. Its conversion to the isomeric coumarino-[3,4-c]-9H-9-methyl-2-oxo-2-phenyl-1,2-oxaphosphole was studied in different reaction condition