✦ LIBER ✦

Synthesis, structure, and conformation of the dilactone derivative of Gd1b ganglioside

✍ Scribed by Giovanni Fronza; Gunther Kirschner; Domenico Acquotti; Sandro Sonnino

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 575 KB
Volume: 195
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(89)85087-6

No coin nor oath required. For personal study only.

✦ Synopsis

Treatment of DG1b, beta-Gal-(1----3)-beta-GalNAc-(1---- 4)-[alpha-Neu5Ac-(2----8)-alpha-Neu5Ac-(2---- 3)]-beta-Gal-(1----4)-beta-Glc-(1----1)-Cer, with dicyclohexylcarbodi-imide in anhydrous methyl sulfoxide affords 95-98% of GD1b-dilactone. The carboxyl groups of the two sialic acid units are involved in ester linkages, as proved by ammoniolysis and reduction which gave derivatives containing the amide of sialic acid and N-acetylneuraminulose, respectively. 1H-N.m.r. spectroscopy showed that the lactone rings involved position 9 of the inner sialic acid and position 2 of the inner galactose and that the disialosyl chain is extended toward the -beta-Gal-(1 ----4)-beta-Glc- portion of the ganglioside moiety.

📜 SIMILAR VOLUMES

Synthesis and structural characterizatio

Synthesis and structural characterization of the dilactone derivative of GD1a ganglioside

✍ Giovanni Fronza; Günther Kirschner; Domenico Acquotti; Rosaria Bassi; Luigina Ta 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 562 KB

Treatment of GD1a [alpha-Neu5Ac-(2----3)-beta-GalNAc-(1----4)-[alpha- Neu5Ac-(2----3)]-beta-Gal-(1----4)-beta-Glc-(1----1)-Cer] with dicyclohexylcarbodi-imide in anhydrous methyl sulfoxide affords 94-98% of GD1a-dilactone. The involvement of the carboxyl groups of the two sialic acid residues in the

A facile, systematic synthesis of gangli

A facile, systematic synthesis of ganglio-series gangliosides: Total synthesis of gangliosides GM1 and GD1a

✍ Akira Hasegawa; Takao Nagahama; Makoto Kiso 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 337 KB

Mammals, birds, amphibians, and teleost fish all have similar brain gangliosides. These gangliosides are of the ganglio-series with predominantly, gangliotetraose, P-o-Gal-(1 + 3)-fl-D-GalNAc-(1 + +&o-Gal-( 1+ 4)-~-Gk, as the neutral oligosaccharide, though with a varying degree of sialylation. Sinc

Synthesis and Conformational Analysis of

Synthesis and Conformational Analysis of Macrocyclic Dilactones Mimicking the Pharmacophore of Aplysiatoxin

✍ Henner Knust; Reinhard W. Hoffmann 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 373 KB

## Abstract A small number of macrocyclic dilactones of type **3**, __i.e.__, **9, 10, 11**, and epi‐**11**, comprising a 3,4‐dihydroxypentanoic acid unit, the pharmacophore of aplysiatoxin, and a conformationally preorganized __ω__‐hydroxynonanoic acid unit were synthesized. Conformational analysi

Immunostaining of ganglioside GD1b, GD3

Immunostaining of ganglioside GD1b, GD3 and GM1 in rat cerebellum: Cellular layer and cell type specific associations

✍ Marie Molander; Claes-Henric Berthold; Håkan Persson; Pam Fredman 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 937 KB

We have studied the cellular distribution of gangliosides GD1b, GD3 and GM1 in rat cerebellum by immunostaining, using monoclonal antibodies and confocal microscopy. Antibodies against astroglial, neuronal and synaptic vesicle associated molecules were used for colocalization analyses. In the gray m

Synthesis and structural conformation of

Synthesis and structural conformation of N-substituted 1,4-dihyropyridine derivatives

✍ M. Mahendra; B. H. Doreswamy; M. A. Sridhar; J. Shashidhara Prasad; A. R. Parech 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 2 views

Synthesis, Structure and Conformation of

Synthesis, Structure and Conformation of Terphenylene-Derived Oxacalixaromatics

✍ Wen-Jing Hu; Xiao-Li Zhao; Ming-Liang Ma; Fang Guo; Xian-Qiang Mi; Biao Jiang; K 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 499 KB 👁 1 views