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Synthesis of orthogonally protected biaryl amino acid derivatives

✍ Scribed by Moreno, Eduardo; Nolasco, Luca Antonio; Caggiano, Lorenzo; Jackson, Richard F. W.

Book ID
119944509
Publisher
Royal Society of Chemistry
Year
2006
Tongue
English
Weight
206 KB
Volume
4
Category
Article
ISSN
1477-0520

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Two synthetic strategies for the generation of differentially protected, chiral tri-amino acids have been developed. The first strategy is based on the reductive amination of a serine-derived oxazolidine aldehyde with mono N-protected ethylenediamine. The second approach involves reductive alkylatio