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Stereoconservative Synthesis of Orthogonally Protected γ-Functionalized Amino Acids Using N -Tritylserine Derivatives

✍ Scribed by Dugave, Christophe; Menez, André


Book ID
118152795
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
181 KB
Volume
61
Category
Article
ISSN
0022-3263

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✍ Christophe Dugave; André Ménez 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 863 KB

The reactivity of electrophiles derived from N-tritylserine, threonine and allothreonine esters toward a selection of nucleophiles was investigated. Best yields from substitution products were obtained with N-trityliodoalanine and soft nucleophiles such as thiols. This strategy was applied to the sy